Diabetes Hypertechnology

Diabetes Hypertechnology

Diabetes Hypertechnology (#150)

John C Pickup ¹

Diabetes Research Group, King’s College London Faculty of Medicine, Guy’s Hospital, London , United Kingdom

Technology is likely to play an increasing role in diabetes care in the next few years, with many expectations and some concerns. Three areas that are receiving particular attention are pumps and sensors, nanomedicine and computing.

A variety of closed-loop insulin delivery systems are being tested, including CGM-connected pumps with predictive low glucose insulin suspend, with or without insulin dosing for hyperglycaemia minimisation, hybrid closed-loop devices with patient-activated meal boluses, as well as fully-closed loop devices. The is increasing evidence for a role for insulin pump therapy in type 2 diabetes, and several new patch pumps are being developed that will be more suitable for this type of diabetes: smaller, less costly and with simpler infusion regimens.

Nanotechnology and nanomedicine applications are likely to include smart insulins with regulated delivery according to prevalent blood glucose levels (a ‘chemical artificial pancreas’), fluorescence-based glucose nanosensors that might be implanted subcutaneously and non-invasively interrogated from outside the body (‘smart tattoos’), and nanofilms for islet cell encapsulation, aimed at extending the survival of transplanted islet cells.

Amongst the many future applications for computers in diabetes care are smart phone or tablet-based apps, cloud-based expert systems for capture of data, management advice and for individual risk assessment – more personalised or precision diabetes medicine.

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Authors contributing to this presentation.

Pickup, J.C

John Pickup is Emeritus Professor of Diabetes and Metabolism at King’s College London and Guy’s Hospital, London, UK. He read physiology for his first degree, followed by a PhD in endocrine pharmacology and then completed his clinical medical training, all at the University of Oxford, UK. After a fellowship at the Endocrine Unit, Massachusetts General Hospital, Boston, and an appointment at the Hammersmith Hospital in London he moved to Guy’s Hospital, London becoming successively senior lecturer, reader and professor. He has also been Visiting Professor at the University of Strathclyde, Glasgow since 2005. His awards include the Banting Lectureship of Diabetes UK, the Diabetes Leadership Award of the Diabetes Technology Society the British Medical Association Book of the Year Award for the Textbook of Diabetes, which he co-edited, and an honorary degree of Doctor of Science from the University of Strathclyde. John Pickup has a long-standing interest in the development and clinical application of novel technology for the improved management of diabetes, starting from the development of insulin pump therapy through to in vivo glucose sensors. His current research focuses on insulin pump therapy and continuous glucose monitoring in clinical practice, developing novel fluorescence approaches to glucose sensing, applications of nanomedicine in diabetes, and activation of the innate immune system and inflammation as a cause of type 2 diabetes and its complications.

Diabetes Hypertechnology (#150)

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