Prevalence of diabetes amongst patients hospitalised with decompensated heart failure and their outcomes — ASN Events

Prevalence of diabetes amongst patients hospitalised with decompensated heart failure and their outcomes (#8)

Kaylyn Khoo 1 , Jeremy Lew 1 2 , Leonid Churilov 3 , Alanna Tan 1 , Raymond Robbins 4 , Libby Owen-Jones 5 , Que Lam 6 , Graeme Hart 7 , Louise M Burrell 2 8 , Douglas Johnson 8 , Jeffrey D Zajac 1 2 , Elif I Ekinci 1 2
  1. Department of Endocrinology, Austin Health, Heidelberg, VIC, Australia
  2. The University of Melbourne, Parkville, VIC, Australia
  3. The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia
  4. Department of Strategy, Quality & Service Redesign, Austin Health, Heidelberg, VIC, Australia
  5. Austin Centre for Applied Clinical Informatics, Austin Health, Heidelberg, VIC, Australia
  6. Department of Pathology, Austin Health, Heidelberg, VIC, Australia
  7. Department of Intensive Care, Austin Health, Heidelberg, VIC, Australia
  8. Department of General Medicine, Austin Health, Heidelberg, VIC, Australia

Background and objectives

We aimed (i) to investigate the prevalence of diabetes amongst patients hospitalised with decompensated heart failure and (ii) to assess the association of diabetes with hospital outcomes and mortality in these patients.

Methods

HbA1c testing was performed on all inpatients aged ≥54 years admitted to a tertiary hospital between July 2013 and January 2016, as part of the Diabetes Discovery initiative. Heart failure admissions were identified using ICD-10 codes. Baseline characteristics were obtained from hospital records. Diabetes was defined as HbA1c ≥6.5%, and pre-diabetes as HbA1c 5.7% to 6.4%. Outcomes were length of stay (LOS), Intensive Care Unit (ICU) admission, 28-day readmission and 6-month mortality.

Results

1191 heart failure admissions with an HbA1c result within 90 days prior to or 7 days post-admission were identified. Of these, 49% had diabetes, 34% had pre-diabetes and 17% did not have diabetes. Patients with diabetes were younger than those with pre-diabetes or without diabetes (Table 1A). Using a multivariable analysis adjusting for age, Charlson comorbidity score and estimated glomerular filtration rate, there was no evidence of diabetes being associated with length of stay, ICU admission or 28-day readmission. However, the presence of diabetes was associated with a lower risk of 6-month mortality (Table 1B). This finding was also supported using HbA1c as a continuous variable.

Conclusions

Nearly half of patients admitted with heart failure had diabetes, with a further one third having pre-diabetes. The presence of diabetes was associated with lower 6-month mortality. These observational data are hypothesis generating. A possible explanation is that patients with diabetes are more likely to be on drugs that prevent cardiac remodelling, such as renin-angiotensin system antagonists, which may modulate the severity of heart failure and its consequences.  Further work is underway to determine the medication history as well as echocardiographic parameters.

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