SGLT2 inhibitors and renal disease — ASN Events

SGLT2 inhibitors and renal disease (#153)

Mark Cooper 1
  1. BakerIDI, Melbourne, VIC, Australia

With increasing choice of glucose lowering drugs for type 2 diabetes it is now possible to select an agent based on the potential of the agent to confer end-organ protection.  The SGLT2 inhibitors appear not only to have a mode of action which is located within the kidney but also based on a number of studies to confer renoprotection, as assessed by a reduction in albuminuria and a stablisation in the decline in GFR.  These effects have been seen with various SGLT2 inhibitors but the most definitive results have been obtained as part of a secondary analysis of the EMPA-Reg study

  1. Wanner et al NEJM 374, 1586-7, 2016
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